It's a good thing Valve has provided us with so many expert murderers and zombie killers.
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Who better than someone who can't die because he just reforms from his scattered bits?
He's killed hundreds of Headcrab Zombies, normal Zombies shouldn't be much of a problem.
Does he really need an explanation?
Black Scottish Cyclops is credit to team!
Once he gets over his addiction to pills, he'd be a great addition
Magical healing Proton pack.
He's proven he can handle his own against the Zombie hordes with relative ease.
Necromorphs are much worse than normal zombies so this would be a cakewalk for Isaac.
He can get in and out of places on supply runs easily.
Who better to fortify our shelter with level 3 Sentries and teleporters?