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The title character of the XBLA game 'Splosion Man. A dangerous folly of man (and science!), originally designed as a weapon, this 'Splosion without a cause fights his way through the ranks of Big Science Labs in a last ditch bid for freedom the only way he knows how, 'Splodin'.
Adler is one of playable characters and minor antagonist in Akatsuki EN-Eins.
Chief alchemist in the Order of the Sword.
A mysterious scientist who works for Kamishiro Enterprises and happens to be investigating the Eaters in Digiimon Story: Cyber Sleuth.
The protagonist of Prototype, Alex Mercer has been transformed by a virus into a shapeshifting weapon. He seeks to uncover the mysterious source of his abilities as well as fight the same virus as it consumes Manhattan.
Alfred Ashford's sister, presumed dead.
Dr. Amanda Kenson is a human scientist most famous for her discoveries around the origin of the Mass Relays.
Andrew Ryan is the founder of Rapture, the undersea Utopia that is the setting for BioShock. His name is a partial anagram of Ayn Rand, author of the novel Atlas Shrugged, which served as the main inspiration for Ryan's philosophies and aspects of BioShock's story.
A genius artificial human whose intelligence rivals Dr. Gero's. Makes her first appearance in Dragon Ball FighterZ.
The arch-rival to Jumping Flash's starring robot, Robbit. Baron Aloha is a self-professed 'Mad Scientist' bent on turning the best parts of the Milky Way into his own private luxury resort.
The inventor of the Mouser, Baxter Stockman is a scientist who is often in the employ of The Shredder. He ends up either a cyborg or a mutant fly depending on the incarnation.
Brain is the disembodied brain of a German scientist. He is the partner-in-crime (and love) of Monsieur Mallah.
Busuzima first appeared in Bloody Roar 2.
Caulder is the primary villain in Advance Wars: Days of Ruin. As director of Intelligent Defense Systems, he's a scientist with zero ethics and believes in advancing his projects by any means necessary.
A former Frontier scientist who participates in the Apex Games to study the effects of his gruesome Nox Gas.
The evil scientist Chingensai has kidnapped the princess.
A time-traveling thief. Father of Gertrude "Arsenic" Yorkes.
A version of Hank McCoy from the Age of Apocalypse universe who harbors no morals and thus is a flat-out evil mad scientist. He's spent a lot of time on the mainstream Earth-616 universe, making trouble for the heroes there.
Admiral Daro'Xen vas Moreh is a member of the quarian Admiralty Board. She is known for her keen scientific interest in the geth.
Dexter is a boy super genius who has built a secret laboratory in his room. This leads to him inventing some crazy things and is the focal point of his adventures. He also has a mysterious German/Russianaccent.
Also known as Dr. Cid, he is one of the central antagonists in Final Fantasy XII and is Balthier's father. After going insane in his mad lust for power through the nethecite, he and his ethereal ally Venat stand in the way of Balthier and his allies.
HYDRA's resident evil psychiatrist.
A doctor who accidentally created a new breed of fire ants that ends up killing almost everyone in grayditch.
Is the main villain in the crash bandicoot games. And a mad scientist who's plan is always thwarted by Crash, who he created. He is thought to be a bit crazy.
A mad scientist who has battled Wonder Woman on several occasions.
Mad scientist obsessed with putting extra butts on animals. Hasn't been seen since the show's early days.
The man who created Crackdown's Super-Human Agents and The Agency's Cloning Program. He is responsible for Crackdown's Freaks
One of the 3 evil doctors in the game Tengai Makyou II: Manjimaru. Specializes in magic.
A cyborg mad scientist dolphin voiced by Neil Patrick Harris.
Dr. Brainius is the deranged villain in the game Dynowarz: Destruction of Spondylus. A former partner of Professor Proteus, now a mad scientist.
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