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He is the main antagonist of the game. The president of Burnital Industries (as well as Dr. Muto's nemesis,) Burnital is the final boss of Mazon.
An antagonist from Dead Space, Challus Mercer is a crazed scientist on the USG Ishimura and extreme Unitology supporter. He tries to hinder Isaac's progress in returning the Marker.
This mad scientist gave himself a cockroach head in an experiment he performed on himself. Although brilliant, he likes to eat garbage.
A mad scientist from the WarioWare series. He invents many gadgets used in the games.
Dr. Curien is the main antagonist in the House of The Dead who plans to rule the world.
DePlayne, boss, DePlayne!
One of the 3 evil doctors in the game Tengai Makyou II: Manjimaru.
One of the 3 evil doctors in the game Tengai Makyou II: Manjimaru. Specializes in bionics.
The evil Dr. Doofenshmirtz is constantly trying to take over the Tri-State Area. His nemesis is Perry the Platypus.
Dr. Dorson is an archaeologist and professor who asks for the aid of Ethan Webar and the GUARDIANS to investigate a newly discovered RELICS site. He appears early in the game 'Phantasy Star Universe' and has a vague connection to Renvolt Magashi.
Drakken is a evil scientist who battles Kim Possible. Like all evil scientist he has a helper, his helpers name is Shego. Drakken is a would-be-world conquerer.
Necrobiologist Dr. Elgin R. Hellman headed a top-secret Pentagon research team exploring the controversial fields of near-death experience, cryogenics, vampirism, ethnobiology and morphology. He disappeared from public life when he was drummed out of the Pentagon a few years ago...
The mad scientist of Halloween Town.
The main character of the 19th century novel Frankenstein and most of its adaptations, Dr. Frankenstein is a scientist who manages to bring a hideous corpse to life. He is often thought to be a progenitor to the "mad scientist" trope.
Dr. Fred Edison is the main villain in the videogame series Maniac Mansion.
Dr. Gero is a scientist that worked for the Red Ribbon Army. When Goku destroyed that organization, Gero swore revenge, and created androids to kill him.
The protagonist (and antagonist) of the novel "The Strange Case of Dr. Jekyll and Mr. Hyde".
Owner of the mansion in which the Splatterhouse games take place. His grotesque spirit was the final boss of the original game, and he appears in a humanoid form in the 2010 reboot.
Dr. Jonathan Jacobo is the main antagonist of Scooby-Doo 2: Monsters Unleashed.
A boss character featured in multiple Clay Fighter games. He has a custom made prosthetic limb that he appears to use for insane scientific pursuits.
A mad scientist and primary antagonist in Dino Crisis.
Dr. Light is a super-villain with light-based powers.
Dr. Malcolm Betruger was the head scientist of the Union Aerospace Corporation (UAC) on Mars. He's voiced by Philip L. Clarke.
Dr. Mashirito is the primary antagonist of the Dr. Slump series.
The mad scientist who created Gossamer, alternatively known as Dr. Frankenbeans or just Evil Scientist.
He is the main character of the appropriately titled Dr. Muto Using his Splizz Gun, Muto can morph into a mouse, gorilla, spider, fish, and flying squirrel, each of which has unique abilities that enable him to complete different stages of the game. His home planet is Midway.
First appeared in Crash Bandicoot 2, replacing Dr N Brio as Dr Neo Cortex's new assistant.
Dr. Ned is the Jakob's Cove doctor. Additionally, Dr. Ned is totally not Dr. Zed from the last story.
Gru's mad scientist friend.
The Main Antagonist of The Ratchet and Clank series and is the most recurring villain. He hates all organic life and is pro-robotocism alone despite formerly being one. He is the Archenemy of Ratchet,Clank,and Captain Copernicus Qwark.
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