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The main antagonist of the "Lilo & Stitch" Game Boy Advance game. He is a robotic mosquito-like alien mad scientist who has Lilo and various aliens kidnapped to feed them to his army of genetically-modified mosquitos.
The psychotic host of "Tales from the Vet" on Muppets Tonight.
Blake Stone's nemesis in both Blake Stone games. He plans to take over earth using mutants, monsters, and modified humans.
Dr. Fred Edison's ancestor, an inventor from the 18th century.
Character in the Mega Man Battle Network franchise. He is the leader of Nebula and the main antagonist of Mega Man Battle Network 4 and 5.
Dr. Robotnik, also known as Dr. Eggman, is the antagonist in nearly every Sonic the Hedgehog title.
Dr. Schabbs is the main boss in Episode 2 of Wolfenstein 3D. His attack consists of thowing syringes at BJ, the hero.
He is one of the few survivors onboard the USG Ishimura. A Unitologist, Kyne begs for the return of The Marker back to the colony.
Dr. Venom is a recurring antagonist in the Nemesis, Gradius, and Salamander series. He developed the Vic Viper and Metalion, but turned rogue when the Gradius government turned a blind eye to the plights of his people.
The main antagonist in Interpol: The Trail of Dr. Chaos.
Main Antagonist of Mega Man Zero 4. he is the former ruler of Neo Arcadia.
Dr. Wily is the insidious inventor of the various Robot Masters that plague the year 20XX. His jealousy and hatred for both Mega Man and Dr. Light has compelled him to mastermind various plots to do away with them throughout several games.
Dr. X is the evil nemesis of Action Man, bent on world domination.
A mad scientist with an abnormally-shaped head who is often an enemy of Ant-Man.
Elexis Sinclaire is the sexy villain from SiN and SiN Episodes who became an avid cover girl for games magazines worldwide around the release of SiN.
The Engineer is a character class in the Team Fortress franchise. He is able to build different structures to aid his teammates in the battle.
An enemy of Pac-Man, from Pac-Man World 3.
A scientist who is an ally of Samurai Jack.
The leader of the Homunculi and the main antagonist of Fullmetal Alchemist.
Once a benevolent and highly respected Imperial Physician, Festus has since become a champion of Nurgle, spreading diseases far and wide instead of curing them.
The mad scientist and teacher from the Soul Eater games. He views everything as being an experiment or as a specimen, including himself.
The Human antagonist of Crysis, Kyong seeks what he believes is an unlimited source of power to make North Korea a force to be reckoned with.
A Cornian lord who joined Zenoira in his efforts to combat and cure the plague that took his wife.
A scientist from the demon world in the Onimusha games
Harlan Wade spent a large amount of his life as a scientist at Armacham. He was the one who kickstarted, and eventually shut down, Project Origin.
Professor Hugo Strange is a comic book supervillain in the DC Comics universe. He is one of Batman's recurring villains.
Iggy is the fourth oldest son of Bowser, a member of the koopalings, and a crazy genius.
High-ranked Skaven of Clan Skyre. A deranged Warlock Engineer obsessed with Warpstones, which he seeks to power his Doomsphere.
Zim is the main character in the cult classic TV show Invader Zim. He has also made appearances in a couple of Nickelodeon-themed games.
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