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The gameplay of Ham-Ham Challenge consists of 12 touchscreen-based puzzle minigames geared towards young children. Unlike previous Hamtaro entries on Nintendo platforms, this game consists of a singular hub world navigated using the touchscreen.
This was the most recently released handheld Hamtaro game. Because the game was released five years after the Hamtaro anime was cancelled in the United States, the US release includes a short cutscene re-introducing each character. Interestingly, the song that plays during the cutscene is from the anime's Japanese intro theme.
The minigame types include: