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Dr. Mario 64 is a falling-block tile-matching puzzle game developed by Nintendo (Company) (along with Newcom) and published by Nintendo for the Nintendo 64 (Platform) exclusively in North America on April 8, 2001.
Part of the Dr. Mario series of puzzle games, Dr. Mario 64 features a variety of new single-player and multiplayer game modes (including support for four-player multiplayer) and a new art style (with both pixel art for gameplay and a hand-drawn "papercraft" style for cutscenes).
In addition to the standard modes, the game features a story mode involving both Dr. Mario and Wario (Character), as they both chase down the villainous Mad Scienstein (Character) to recover Dr. Mario's bottle of Megavitamins. Sometimes seen as a tie-in to the Game Boy Colorgame Wario Land 3 (Game), both protagonists encounter numerous enemy creatures from that game.
The game was later ported to the GameCube (Platform) as part of the Japanese-exclusive Nintendo Puzzle Collection (Game), and later received a digital release for the Nintendo Switch (Platform) outside of Japan on October 25, 2021 as part of the original platform's Nintendo Switch Online service. It was also one of 14 games released for the 2003 mainland Chinese console iQue Player.
These modes are first-to-three competitive modes, which can be played in two-player (either Human-vs-CPU or Human-vs-Human) or four-player settings (with any configuration of Human and CPU players).
In these modes, players can send garbage blocks to their opponent through larger clears and chain clears. In four-player multiplayer, the game determines who receives another player's attack by the colors made from the first clear (with Blue affecting the first available player to the right, Yellow the second, and Red the third, looping around to the far left).
Each of the characters have their own CPU level when used as opponents. They can be made more difficult through a hidden button combination.
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