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Diatomic is an arcade shooter exclusive to WiiWare and plays similar to ' Geometry Wars and' flOw. The player controls a "diatomic protagonist" equipped with various weapons to use to defend their petri dish. The player must destroy various different enemies with the help of the randomly spawning power-ups to keep them out whilst building up bonuses and multipliers to rank higher on the leaderboards.
In total there are seven different types of enemies which the player must destroy. All enemies have their own unique combo moves apart from the DIalbouros.