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After receiving a frantic phone call from his old friend Doctor Cooger, Cole finds himself in a world of nightmares, as a chemical formula for the reanimation of dead tissue causes a city-wide infestation of the undead. With the Doctor's assistant Sheila in tow, Cole must brave the zombie hordes in his search for a way to stop them.
As they move through the city, they encounter a rag-tag band of survivors, including a soldier, a journalist, a private investigator, some small-time criminals, and a former police captain with a hidden agenda.
(Names include some romanisation of original Japanese)
Set in a generic North American city, locations include:
The final act of the story takes place in a top-secret scientific complex, partially concealed beneath the city. With this in mind, it may be interesting to compare the locations featured in Dead of the Brain to those featured in the early Resident Evil (Franchise) games.
Apart from the MSX (Platform) version, the game features a traditional point and click interface. The MSX (Platform) version uses plain Japanese text menus for all interactions. The MSX (Platform) version also lacks several UI elements present in the other versions.
Though the MSX (Platform) version is less graphically impressive, the Sharp X68000 (Platform), PC 9801 and FM Towns (Platform) versions feature improved graphics and occasional spot animations. Sound and music is also noticeably improved in these versions, due to advanced sound processing hardware.
All home computer versions feature a small amount of mild to moderate nudity and sexual content, though substantially less than traditional Eroge (Concept) games.