Crypto is back for more destruction on humanity, and this time he's ready for war, not love! More than a decade has gone by since Crypto defeated Majestic and took over the American government in the cult classic sensation that was Destroy All Humans. Now it's 1969, and Orthopox 13 has died after a Soviet nuclear missile destroyed the Furon mothership five years earlier in 1964. Pox has downloaded his consciousness into a personal holographic projector designed to communicate between Furons on Motherships and planet surfaces. Pox's unit, dubbed a HoloPox, allows him to communicate with, advise, and vex Crypto down on Earth. Crypto 137 has died of unknown causes, and Crypto 138, a clone with pure Furon DNA harvested from human brains, has taken his place as the President. Crypto 138 is the first Furon in millennia to possess genitalia, as his pure DN has not been corrupted by radiation. When the KGB destroy the mothership and Pox, Crypto must find a way to stop them from destroying what he has worked so hard to achieve. Along the way, he is supported by Natalya Ivanova, a rogue KGB agent whom he constantly hits on. He also comes across the Blisk, the dreaded enemy that the Furons thought they defeated in the Martian War.
This sequel is even more exciting than the original! The humor of this is dark humor. It typically takes place during conversations between Crypto and Orthopox who make fun of the human race and their customs, but the humans in the games are often parodies of certain types of humans (especially the hippies). The additional cutscenes have epic imagery and funny voice acting. Unfortunately the graphics (especially the human models) didn’t seem to age enough, which is rather jarring when you especially consider the Reprobed version.
The game is once again an open world game. While you can follow the missions, you can also just roam around, randomly kill humans, and complete side missions. Once more, the environments allow for a lot of enjoyable destruction and fun combat involving killing humans using various weapons such as the Meteor Strike, the Gastro Gun, the Disintegrator Ray, and the Ion Detonator, among others. In fact the new weapons and body snatching ability just add more fun to a game with huge open worlds and the plentiful side missions; however, it is not possible to Transmog in human form.
The AI in the game is unfortunately flawed. Every enemy seems as brain dead as Crypto thinks they are. For example, the final boss is very dull & easy to beat. And as always with escort missions in any piece of interactive art, Natalya's escort missions have become godawful.