PROS

• Original characters are animated at a very high quality with matching voicework
• Each fighter has their own remix of the Punch-Out music
• Single player replay value is high
• Challenge mode has a "puzzle game" quality to it
  
• Title Defense mode makes this the most challenging Punch-Out overall
• Practice mode and autosave removes the trial-and-error of previous Punch-Outs

CONS

• Relies heavily on nostalgia to fully appreciate
• No "final boss" like Mike Tyson or Mr. Dream.  Donkey Kong is more of a novelty fighter.
• Not enough fighters.  Could've included more Super Punch-Out fighers to the roster
• Remote + Nunchuck controls not ideal for the fast response time required
• 2 player splitscreen is basically a counterpunch game
• $50 retail price is kinda high for the content.  Remakes are usually priced lower (eg Space Invaders Extreme, Bionic Commando Rearmed, Pacman Championship, etc).