I restarted from the beginning when the 1.0 build came out, having never even beaten the first boss despite 50 or so runs. My very first run after restart I made it all the way to the throne room with an ice bow and twin daggers. The ice bow had piercing and 4x slowdown on it, so for every situation I'd just freeze the two closest enemies and beat the hell out of them with the daggers and kill them before they'd have a chance to attack. Still waiting for another ice bow to drop though. :-(
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