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Picross S6 is a puzzle game developed and digitally published by Jupiter for the Nintendo Switch on April 22, 2021. The sixth mainline entry in the Picross S series (and the sequel to Picross S5 (Game)), Picross S6 features a new set of 300 standard nonogram puzzles (for Picross and Mega Picross modes), 5 multi-part "Clip Picross" puzzles, 30 Color Picross puzzles, and 5 Extra puzzles. In addition, this entry introduces multi-colored grids, allowing players to differentiate every 5th row and column.