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Abbott is one of the antagonists in The Chronicles of Riddick: Escape from Butcher Bay.
A recurring Hulk villian. A former KGB agent who deliberately exposed himself to the same radiation that transformed Bruce Banner.
Ad Avis is one of the main antagonists of the Quest for Glory franchise. He first appears in Quest for Glory II: Trial by Fire
An evil wizard who wants to rule the forest which was expelled.
A charismatic Admiral who is one of the main antagonists in the Wing Commander franchise.
Kobel is the chief architect and commanding officer of the Earth Defence Force on Mars.
As the leader of the Nazis, Adolf Hitler has appeared as an antagonist in several video games. Commonly considered the worst person ever, if you get the chance to kill him, you probably should.
An antagonist in Dead Island. He stole the Island's boat.
The main antagonist of A Link to the Past, Agahnim is an evil wizard and the alter-ego of Ganon.
The main antagonist of the Matrix franchise.
A mysterious scientist who works for Kamishiro Enterprises and happens to be investigating the Eaters in Digiimon Story: Cyber Sleuth.
The acting chairman of Ohtori Academy in the anime Revolutionary Girl Utena, as well as Anthy's older brother and the series' eventual antagonist.
A crazed doctor and recurring antagonist in Resident Evil: Outbreak File #2's Flashback scenario.
Owner of Al's Toy Barn in Toy Story 2
Alak-Hul, the Darkblade is a Hive Darkblade Knight, foster son of Oryx, the Taken King, and the boss of The Sunless Cell Strike. After being killed by the Guardians, he was resurrected years later as Alak-Hul, the Lightblade by a Hive Ghost of the Lucent Brood, and became the boss of The Lightblade Strike.
The leader of the Black Knights.
A traitor and enemy to the vast majority of Resident Evil's protagonists, Albert Wesker has rapidly achieved super-villain status within the series canon.
Dictator of Guarma and antagonist in Red Dead Redemption II.
The main villain of Scarface.
One of the main male characters in Resident Evil Code: Veronica. He is a descendant of one of the founders of Umbrella.
The younger brother of Maya Schröedinger in Wild Arms 3.
Algol, the Hero King, is the final boss in the game Soul Calibur IV, and is the creator of Soul Calibur. Algol wields both Soul Edge and Soul calibur . He is also said to hide ten distinct weapons in his body, like a cannon that forms around his hand.
The AI responsible for the collapse of humanity in the game I Have No Mouth and I Must Scream. Kept 5 humans alive to torture for 109 years.
Amakusa is the main antagonist in the ''Samurai Shodown'' fighting game series.
Amon is an antagonist in the legend of korra.
Ancano is a character that appears in The Elder Scrolls V: Skyrim and The Elder Scrolls: Legends, the Heroes of Skyrim expansion. He is an Altmer Mage in the College of Winterhold.
Andre is an enemy to Rayman. He leads an army of black lums and is bent on corrupting the heart of the world. In Rayman 3: Hoodlum Havoc, Globox accidentally swallows Andre, and it takes 3 teensie doctors to get him out.
Pinkerton Agent who serves as the main antagonist of Red Dead Redemption II.
Andrew Ryan is the founder of Rapture, the undersea Utopia that is the setting for BioShock. His name is a partial anagram of Ayn Rand, author of the novel Atlas Shrugged, which served as the main inspiration for Ryan's philosophies and aspects of BioShock's story.
Finished long after Dr. Gero's death by his self-aware supercomputer, Android 13 is specifically designed to destroy Goku. He can obtain a greater form once absorbing components from #14 and #15.
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