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The Protheans were once believed to be a single race that spanned the known galaxy with a mighty empire. But it has been revealed that in fact 'Protheans' were a mix of all known alien species unified under one name and empire. 'They' were wiped out by the reapers.
In the Mass Effect franchise, the Reapers are a hyper-advanced machine race that appear periodically every 50,000 years to bring a close to a "cycle" in which the Reapers harvest all the advanced forms of life.
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