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A member of the CIA, Roger McCoy acts as the leader in Metal Gear Acid.
Main protagonist of Murdered: Soul Suspect, O'Connor is searching for the man that murdered him.
The leader of the Fur Fighters. Roofus is a playable character of the Fur Fighters video games.
Roy Earle is a detective who works the Administrative Vice desk in L.A. Noire. He is played by Adam Harrington.
Sai is a character who appears in the Akatsuki EN-Eins series.
Main antagonist in Mafia III.
Known as the "ultimate predator," Sam Fisher is the protagonist of the Splinter Cell franchise.
A drug addict and former prostitute who becomes a victim of the Jigsaw killer.
Saren Arterius is the main antagonist in first Mass Effect. He is also the longest serving Turian agent in the elite SPECTRES.
Sazh Katzroy, an airship pilot by trade and a father of a young boy, finds himself caught up in a whirlwind series of events that inevitably sets him on his grand journey.
Scott Shelby is one of the four playable characters in Heavy Rain. He is a private detective investigating the case of the Origami Killer.
The Scout is the fastest and most fragile class in the Team Fortress franchise. His great speed is useful in objective based game types.
Sean Darcy is an Alpha Protocol field agent who specializes in gadgets.
Sean Devlin is the main protagonist from The Saboteur. There's nothing he won't do to put the hurt on the Nazis in general and Kurt Dierker in particular. Voiced by Robin Atkin Downes.
Sean "Sweet" Johnson is CJ's older brother, and believes that Carl is to blame for the death of their younger brother Brian. Sweet, a powerful and uncontrollable figure, heads up the Grove Street Families.
Selene is considered the most powerful vampire within the Underworld fiction, fused with the first true immortal blood. She is portrayed as the heroine in both Underworld films and video game and seen in comicbooks and fictional novels.
Father of Olga Gurlukovich and leader of a Russian mercenary group who seeks to bring Russia back to power.
Don Morello's younger brother and top earner for the Morello crime family.
Sgt. "Roach" is playable character in Modern Warfare 2. As a member of Task Force 141, he serves under Capt. "Soap" MacTavish.
Jackson is one of the two playable characters in Call of Duty 4. He is a member of the Force Recon squad searching for Al-Asad at the beginning of the game.
Shane Carpenter is the protagonist of the first-person shooter, Haze.
Shaundi is one of the lieutenants in the Third Street Saints.
A subway cop who fights with a pigeon and a handgun.
The main character from Crusader: No Remorse, and Crusader: No Regret.
Sion Eltnam Atlasia is the main heroine Melty Blood series.
Smash is a hot-headed member of the elite unit of Blackwater known as Agile-22.
Sokolov was mislead and blackmailed in MGS3 into developing a dangerous weapon known as the Shagohod.
The Sole Survivor is the protagonist of Fallout 4.
Solid Snake is the main protagonist in a number of the Metal Gear games. An expert in infiltration and espionage, Snake has completed countless missions and is repeatedly tasked with disarming the latest incarnation of Metal Gear. He is voiced by David Hayter in the English versions, Akio Ohtsuka in Japanese.
Al Simmons, a murdered government agent, came back from Hell to lead Satan's armies as a hellspawn, imbued with a living demonic suit of armour and incredible powers, but rebelled against the forces of evil and uses his dark power to fight for the side of good.
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