@newfangled: I think Garrus + Wrex were perhaps the best combat-focused party members you could put together in the first game. I'm expecting a fair amount of disagreement on this--everyone has their preferences. My heart stopped when you said you made it to the Thorian without your teammates at your side. That sequence can be extremely punishing. Glad to hear things are moving along for you, though.
@probablytuna, @zevvion: RE: Vanguards on Insanity in Mass Effect 2:
Vanguards, in my mind, are the second-best class with which to tackle ME2's highest difficulty, with Infiltrator being the best. Infiltrators have the advantage of being able to execute their offense with little personal risk--their tactical cloak + sniper rifle combination results in some of the highest per-shot damage values in the game. By contrast, Vanguards MUST be hyper-aggressive at all times, in every combat scenario. This requires quick decision-making and on-the-fly risk evaluation, which is subject to greater influence from human error or the class's sometimes-inconsistent powers--there is one important combat scenario in which the Vanguard's Biotic Charge reacts awkwardly to the level geometry. In this specific instance, the Vanguard tends to get hung up on cover and invisible barriers, which leaves the player without shields and completely exposed to enemy fire. A certain, sudden death on Insanity.
That aside, the Vanguard can literally take down some of the game's hardest enemies on its own, without the help of the team. It is, at peak possible skill, the single most destructive class in the game. (Minor spoilers below--this is a relatively major combat scenario, but it is not plot-focused):
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