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The protagonist of Prototype, Alex Mercer has been transformed by a virus into a shapeshifting weapon. He seeks to uncover the mysterious source of his abilities as well as fight the same virus as it consumes Manhattan.
Dr. Bradley Ragland works in the morgue of St. Paul's Hospital. Though he refuses to work with Blackwatch forces, he aids Alex Mercer in his attempt to contain the viral outbreak.
The sister of Alex Mercer, Dana Mercer investigates Gentek's research into biogenics. She works with her brother in the hope of exposing Gentek for their crimes against humanity.
Colonel Ian Taggart commands the Blackwatch troops deployed on Manhattan Island. They are tasked with containing the viral outbreak that plagues the city.
General Peter Randall is in charge of the entire military operation to contain the viral outbreak on Manhattan Island. He is willing to take any measure to contain the infection.
Dr. Raymond McMullen is the head of research at Gentek, a company performing viral research for Blackwatch.
Captain Robert Cross works for Blackwatch as a specialist operative. Both he and the men under him are tasked with the singular goal of hunting and capturing or killing Alex Mercer, codename Zeus.
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