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Ludwig von Tökkentäkker is the main antagonist from CarnEvil.
The main antagonist of A Link to the Past, Agahnim is an evil wizard and the alter-ego of Ganon.
Chief alchemist in the Order of the Sword.
The Axem Rangers are a boss in Super Mario RPG for the SNES that parody the Power Rangers.
In No More Heroes, Bad Girl is the #2 ranked member of the UAA. Travis fights her in the basement of the Santa Destroy baseball stadium.
Beppi The Clown is the boss of the Carnival Kerfuffle level of Inkwell Isle Two in Cuphead
Hulk enemy with two faces in one, each with its own personality.
The Black Guardian is summoned by Pious Augustus to guard against the theft of the artifact of the Ancient his master is weak against. Its form depends on the alignment path chosen at the game's start.
AI robot designed to assassinate Raiden but then later gets reprogrammed to fight alongside with him.
Giant bird who has tangled with Wario a couple of times.
Booster is a greedy man-child who loves trains and owns Booster's Tower. He kidnaps Princess Toadstool with ambitions to marry her until his plans are foiled by Mario and the gang.
Bouldergeist is a boss in Super Mario Galaxy.
Bowser is one of the most iconic villains in gaming. His role as the main antagonist in the Mario franchise has cemented this King of Koopas' status in video game history.
An aquatic robot master from Mega Man 2. His weapon is the Bubble Lead.
Cagney Carnation is one of the bosses in Cuphead.
One of the bosses in Cuphead, she seems to have a playful and flirtatious attitude.
Captain Brineybeard is a pirate, boss of the Shootin N' Lootin level of Inkwell Isle Three in Cuphead
A Captain of the Grineer race and recurring boss battle in Warframe.
Camilla is a barefoot vampiric worshipper of Dracula, and has more than once attempted to stop the Belmont clan from destroying Dracula. Her vampiric "daughter" is Laura.
A robot master from Mega Man 6. His weapon is the Centaur Flash.
Kalom, bearing the title of Cor was a high-ranking guru in the Brotherhood of the Sleeper, receiving visions from the Sleeper itself.
The taller of the two frog bosses of the Clip Joint Calamity level of Inkwell Isle One in Cuphead
Timmy's evil teacher who tries to prove that fairy godparents exist.
Another of Dr Light's mechanical men who goes berserk after being reprogrammed by Dr Wily. Built for forestry, attacks with giant scissors.
Damnd is the boss of the first level in Capcom's Final Fight.
The right-hand man of Count Dracula, Death is easily recognized by his giant scythe and ominous cloak. Not the same Death who appears in other games.
10th ranked assassin in No More Heroes. Cut down by Travis Touchdown on his way to the top.
A shapeshifting Genie who is among the many bosses in Cuphead
Also known as Dr. Cid, he is one of the central antagonists in Final Fantasy XII and is Balthier's father. After going insane in his mad lust for power through the nethecite, he and his ethereal ally Venat stand in the way of Balthier and his allies.
Doviculus is the main antagonist in Brütal Legend and is the leader of the Tainted Coil. He was originally supposed to be voiced by Ronnie James Dio but is now being voiced by Tim Curry.
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