The Wine compatibility layer is a Linux-package making it possible to play Windows games within the comfort of a Linux-system. While Wine can be a bit tricky to use for those new to Linux, it is the backbone of a few frontend programs, such as "play-on-linux" and Cedega, which handles everything from installation to running the game without the player ever having to consult a terminal.
Games run in wine with various levels of success. An example of a game that works almost flawlessly is World of Warcraft, with players reporting better framerates within the "emulated" environment compared to a proper windows installation.
Also notable to gaming is that the Steam platform works perfectly in modern versions of wine, allowing a variety of games to be installed (though games installed via steam are no more or less likely to function properly).
The wine application database holds information about most tested applications, often with good instructions on how to get a game working.
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